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Explore the biophysical foundations of genome function through an in-depth scientific lecture examining how DNA mechanics and nucleosome condensability influence cellular processes beyond traditional genetic and epigenetic mechanisms. Discover how mutations can alter genome function through changes in DNA mechanical properties rather than just amino acid sequences or transcription factor binding sites. Learn about the direct effects of histone modifications on nucleosome biophysical characteristics and their impact on chromatin organization. Examine cutting-edge research utilizing single molecule methodologies and genome-scale sequencing techniques to quantify the roles and magnitudes of DNA mechanics in genome maintenance and chromatin function. Gain insights into how DNA flexibility, nucleosome stability, and condensation properties serve as fundamental biophysical parameters that influence cellular processes including DNA replication, repair, transcription, and epigenetic regulation. Understand the intersection of physics and biology in genome maintenance, including the development of single molecule force sensors and measurements of force loading rates within living cells. Delve into advanced concepts of genome organization in three-dimensional space and the complex interplay between ongoing nuclear processes and chromatin structure.
