Center for Physical Genomics and Engineering Courses

Mechanisms of Chromosome Folding and Gene Expression

Delve into chromosome folding mechanisms, exploring how DNA organization affects gene expression, replication, and cell division through phase separation and loop formation by molecular motors.

• YouTube
• 1 hour 14 minutes
• Self-Paced
• Free Video

Investigating Rapid Nuclear Mechanotransduction by Mapping Genome-wide Changes in Transcription

Explore groundbreaking research on nuclear mechanotransduction, examining how mechanical forces rapidly influence gene activation and chromatin accessibility through PRO-seq and ATAC-seq analysis.

• YouTube
• 53 minutes
• Self-Paced
• Free Video

Quantifying the Physical Genome - Understanding Regulatory Elements and Transcription Factor Dynamics

Delve into groundbreaking research on genome regulation, exploring how transcription factors and regulatory elements control gene expression and cellular diversity in human development through advanced sequencing methods.

• YouTube
• 1 hour 18 minutes
• Self-Paced
• Free Video

Role of Motors in Genome Folding

Explore the physics of chromosome folding, focusing on ATP-consuming motors' role in loop formation and mitotic structures. Learn about analytical models and their implications for genomic organization.

• YouTube
• 48 minutes
• Self-Paced
• Free Video

ATP-Dependent Remodeling of Hexasomes, Nucleosomes and Chromatin Condensates

Explore ATP-dependent chromatin remodeling, focusing on INO80's unique hexasome preference and its impact on higher-order chromatin organization. Gain insights into novel mechanisms regulating genome accessibility.

• YouTube
• 58 minutes
• Self-Paced
• Free Video

Epigenomic Landscape of Retrotransposon Expression in Senescence and Neurodegeneration

Explore the activation of retrotransposons in aging and neurodegeneration, focusing on LINE-1 elements' role in cellular senescence and potential implications for neurodegenerative diseases.

• YouTube
• 58 minutes
• Self-Paced
• Free Video

Many-to-Many Networks: Multifunctional Modules for Multicellularity

Explore how many-to-many protein networks function as versatile computational devices in multicellular organisms and their potential applications in synthetic biology for designing complex behaviors.

• YouTube
• 51 minutes
• Self-Paced
• Free Video

Mechanisms and Applications of DNA Methylation and Gene Silencing in Plants

Explore DNA methylation in plants, its role in gene silencing, and CRISPR-based tools for targeted methylation changes in research and crop improvement.

• YouTube
• 46 minutes
• Self-Paced
• Free Video

Capturing Biomolecular Interactions at Single-Molecule Level via ABEL Trap Fluorescence Spectroscopy

Explore cutting-edge ABEL Trap fluorescence spectroscopy for observing single-molecule biomolecular interactions, presented by Dr. Allison Squires of the University of Chicago.

• YouTube
• 29 minutes
• Self-Paced
• Free Video

Investigating Gene Activation Dynamics in Human Polycomb Chromatin with Synthetic Reader-Effectors

Explore gene activation dynamics in human polycomb chromatin using synthetic reader-effectors. Gain insights from Dr. Karmella Haynes' research on applying chromatin properties to engineer proteins controlling cell development.

• YouTube
• 36 minutes
• Self-Paced
• Free Video

Modeling of Nucleosome Clustering in Euchromatin Resulting from Reader Protein Interactions

Explore nucleosome clustering in euchromatin through modeling interactions between reader proteins. Gain insights into chromosomal organization and dynamics from the Spakowitz lab's research.

• YouTube
• 25 minutes
• Self-Paced
• Free Video

Ultraresolution Imaging Through Deep Tissue and Information-Based Theoretical Resolution Limit

Explore ultraresolution imaging techniques for deep tissue and discover a novel information-based theoretical resolution limit in this cutting-edge biomedical engineering presentation.

• YouTube
• 31 minutes
• Self-Paced
• Free Video

Super-Resolution Imaging of Chromatin Structure and Dynamics in Health and Disease

Explore super-resolution imaging techniques for chromatin structure and dynamics in health and disease with Dr. Melike Lakadamyali's cutting-edge research and insights.

• YouTube
• 32 minutes
• Self-Paced
• Free Video

Gene Regulation in Cellular Senescence

Explore gene regulation in cellular senescence with Prof. Masashi Narita, uncovering key insights on epigenetic aspects and senescence-associated heterochromatic foci (SAHFs).

• YouTube
• 35 minutes
• Self-Paced
• Free Video

3D Chromatin Rewiring During Melanoma Phenotypic Transition

Explore 3D chromatin architecture's role in melanoma phenotype transitions. Discover how MITF and mechanical factors influence chromatin folding and gene expression in cancer progression.

• YouTube
• 1 hour 2 minutes
• Self-Paced
• Free Video