Investigating Enhancer DNA Methylation Dynamics Using 6-Base Genome Analysis

Join a 56-minute webinar featuring Dr. Emily Hodges, Assistant Professor of Biochemistry at Vanderbilt University, as she presents groundbreaking research on enhancer DNA methylation dynamics during cellular differentiation. Learn how the innovative 6-base genome solution and duet multiomics solution evoC provide unprecedented insights into the correlation between methylation states and chromatin accessibility across the genome. Discover how genome-wide detection of 5-hydroxymethylcytosine reveals active demethylation processes preceding chromatin and transcription factor activity, while exploring the persistent nature of enhancer hypomethylation. Gain understanding of how timepoint-specific methylation states can predict chromatin accessibility through machine learning models. Explore the advantages of single-base resolution data in identifying changes at individual gene enhancers and their impact on gene regulatory programming. Delve into the capabilities of combinatorial genetic and epigenetic technology that distinguishes between 5-methylcytosine and 5-hydroxymethylcytosine on the same DNA molecule, offering enhanced potential for disease association detection, biomarker identification, and disease progression monitoring.