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Learn the fundamental principles and applications of spatial transcriptomics technologies in this 51-minute educational lecture from the Broad Institute's Medical and Population Genetics Primer series. Explore how these cutting-edge techniques enable researchers to analyze gene expression patterns while preserving spatial information within tissues, providing crucial insights into cellular organization and function. Discover the various spatial transcriptomics platforms, their technical capabilities, and limitations, along with practical considerations for experimental design and data analysis. Understand how spatial transcriptomics is revolutionizing fields such as developmental biology, cancer research, and neuroscience by revealing the spatial context of gene expression in complex tissues. Gain insights into data interpretation strategies and learn about the computational tools and statistical methods used to analyze spatial transcriptomics datasets. This primer is designed for research technicians, graduate students, postdoctoral fellows, and established investigators entering the field who want to understand how spatial transcriptomics can be integrated into their research programs to address questions about tissue architecture and cellular interactions.
