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Watch a research showcase featuring three PhD students from the Physical Genomics Training Program presenting their cutting-edge research on genomics and chromatin biology. Explore how the intranuclear environment regulates nucleosome core particle charge through molecular theory that accounts for salt concentrations, pH, and ion interactions, with particular focus on how magnesium ions modulate charge states. Discover deep learning approaches to modeling RNA translation initiation in human cells, including neural networks that predict canonical and non-canonical translation sites across the genome and their implications for understanding gene expression in diseases like cancer. Learn about the role of heterochromatin protein 1 alpha (HP1α) in stabilizing chromatin packing domains through advanced microscopy techniques including Dual Partial Wave Spectroscopic microscopy and Stochastic Optical Reconstruction Microscopy. Gain insights into how transcription and chromatin organization create hierarchical genome structures, and understand the potential for manipulating transcriptional memory in aging and cancer contexts. The presentations demonstrate the interdisciplinary nature of physical genomics, combining molecular theory, computational modeling, and advanced imaging to address complex questions in chromatin engineering and gene regulation.
