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Explore how cancer-induced nerve injury creates immunotherapy resistance through this comprehensive webinar examining perineural invasion (PNI) as a critical factor in poor cancer prognosis. Discover groundbreaking research using multi-omics approaches and spatial analysis techniques on patient-derived samples to uncover the mechanistic roles of PNI and cancer-induced nerve injury (CINI) in anti-PD-1 therapy resistance across cutaneous squamous cell carcinoma, melanoma, and gastric cancer. Learn how cancer cells degrade nerve fiber myelin sheets through electron microscopy and electrical conduction analyses, triggering autonomous neuronal responses that initiate IL-6 and type I interferon-mediated inflammation for nerve healing and regeneration. Understand how increasing CINI burden creates chronic inflammation that shifts the tumor microenvironment toward a suppressive and exhaustive immune state. Examine therapeutic strategies to reverse CINI-driven anti-PD-1 resistance, including tumor denervation, conditional knockout of neuronal transcription factors like Atf3, interferon-α receptor knockout, and combination therapies using anti-PD-1 and anti-IL-6 receptor blockade. Gain insights into the direct immunoregulatory roles of CINI, the independent inflammatory capacity of neurons, and the critical importance of spatial analysis in identifying novel immunotherapy resistance mechanisms for advancing cancer treatment approaches.
