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Join a 46-minute webinar led by Dr. Biswajit Das, Senior Principal Scientist at Frederick National Laboratory for Cancer Research, exploring the implementation and validation of Comprehensive Genomic Profiling ctDNA panel in NCI trial research. Learn about the technical aspects of ctDNA profiling assays, focusing on how the panel detects complex biomarkers including tumor mutational burden, microsatellite stability status, mutations, and copy number variants in plasma samples. Discover the analytical validation process and real-world applications through case studies from the NCI-MATCH trial, where the Illumina ctDNA assay successfully identified key mutations in plasma samples when tissue-based testing was unavailable. Examine the impressive results showing over 88% positive percentage agreement in variant identification compared to tissue-based profiling in gynecological cancer cases. Gain valuable insights into the technical performance evaluation of ctDNA profiling assays and their practical application in clinical trials from an expert with more than a decade of experience in genomic assay development and ctDNA biomarker research.
