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Explore the discovery of a hidden gene in herpes simplex virus 1 (HSV-1) and its critical role in neurovirulence through this 55-minute Journal of Virology Seminar Series webinar. Learn how researchers Drs. Akihisa Kato and Yasushi Kawaguchi uncovered the cryptic gene UL31.6, which was hidden in plain sight within the well-studied HSV-1 genome, and revealed its unexpected function as a neuron-specific virulence factor. Discover the innovative combination of ribosome profiling, proteomics, and classical virological methods used to identify this gene and demonstrate its critical role in viral spread and neurovirulence. Gain fresh insights into tissue-specific pathogenicity mechanisms and examine how this discovery challenges long-held assumptions about HSV-1 biology. Understand the implications of cryptic genes in viral pathogenesis and their potential as targets for therapeutic intervention. Access accompanying research papers, presentation slides, and resources for further study in viral genetics and neurovirology.
