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Explore a comprehensive lecture by Professor Jose Onuchic from Rice University examining the theoretical modeling of genome folding from a physicist's perspective. Delve into the mechanics of how the human genome folds into 3D structures using the minimal chromatin model, which combines experimental data with theoretical physics principles. Learn about the application of neural networks to interpret chromatin types through epigenetic marks, and understand how the resulting structural simulations align with both HI-C data and microscopy measurements. Discover insights into chromosome territories, chromatin phase separation, and the two-state transitions of chromatin segments, while examining potential mechanisms linking chromatin structure to gene expression control. The presentation, delivered as part of the Statistical Physics in Living Matter series, offers a unique interdisciplinary perspective on understanding genome organization through the lens of physics.
