Coursera Flash Sale
40% Off Coursera Plus for 3 Months!
Grab it
Learn about a critical development in vaccine research through this informative video examining the suspension of a pediatric RSV mRNA vaccine trial. Explore the details of a Phase 1 trial involving Moderna's mRNA-1345 and mRNA-1365 vaccine candidates, which was halted due to safety concerns. Understand the trial structure involving different age cohorts of children under 5 years, dosage levels, and the emergence of severe respiratory disease safety signals. Examine the specific data showing an imbalance in RSV severe lower respiratory tract illness cases between vaccine and control groups, including concerning hospitalization cases. Gain insights into the Vaccines and Related Biological Products Advisory Committee's response and their current deliberations on criteria for trial resumption. Follow along with referenced FDA documentation and contemporary pediatric reports while learning about vaccine-associated enhanced respiratory disease and its implications for future mRNA vaccine development.
