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Explore how new approach methodologies (NAMs) and microphysiological systems (MPS) are revolutionizing preclinical research and improving therapeutic development success rates in this 28-minute webinar presented by Dr. Mark Mondrinos from Tulane University. Learn about the critical importance of incorporating individual physiological differences, particularly biological sex and hormone status, into microphysiological systems to enhance preclinical science outcomes. Discover how sex-specific cell culture methods using estradiol for female cells and dihydrotestosterone for male cells can address baseline differences in bioassays and create more accurate disease models. Examine the application of these methodologies to diabetic retinopathy research, where sex-matched combinations of primary human retinal microvascular endothelial cells and ocular fibroblasts are used to construct MPS models of endothelial barriers and vascular beds. Understand how estradiol provides protective effects against pathological changes in female but not male models, findings that align with clinical observations of increased disease incidence and severity in male patients. Gain insights into how these sex-specific approaches can enable investigation of precision therapies targeting sex hormone signaling in diabetic retinopathy and other diseases, ultimately advancing the development of more effective and personalized treatments.
