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Explore the fundamentals of bioelectricity in the mammalian nervous system through this comprehensive 12-hour course covering passive and active forms of electric signaling in both intracellular and intercellular communication at atomic, molecular, and engineered device levels. Master the basic organization of the central and peripheral nervous systems, neural circuits, and electrical signals in cells while learning to calculate resting potentials using the Nernst equation. Delve into the chemical basis of bioelectricity including ion channels, neurotransmitters, post-synaptic receptors, and pathological conditions. Analyze biological conductors through core conductor models and cable theory, progressing to time-dependent solutions for signal propagation. Study the groundbreaking Hodgkin-Huxley model of action potentials, including its derivation and insights into ionic conductances. Apply bioelectricity principles to real-world medical applications including Parkinson's disease, epilepsy, drug addiction, targeted muscle reinnervation, and optogenetics. Develop computational skills through discrete-time solutions using Euler and Runge-Kutta methods, culminating in Python implementation of Hodgkin-Huxley solutions. Examine bioelectric measurement systems including analog front ends, filtering techniques, analog-to-digital conversion, and complete prosthesis control systems. Gain expertise in neuromodulation using nano-engineered sensors and actuators for advanced biomedical applications.
