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Learn about cancer drug persistence through mathematical modeling in this 46-minute conference talk where Herbert Levine from Northeastern University explores how tumors develop resistance to targeted therapies. Discover how a small minority of cancer cells adopt quiescent states to avoid cell death during treatment, eventually leading to tumor recurrence and genomic resistance. Examine the innovative approach of treating drug persistence as a continuous quantitative trait governed by drift-diffusion equations that depend on drug concentration and epigenetic state. Compare theoretical results with experimental data from EGFR-dependent non-small-cell lung cancer studies conducted across multiple cancer biology laboratories, gaining insights into the mathematical frameworks used to understand and potentially overcome therapeutic resistance in cancer treatment.
