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Advanced Biochemistry

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Overview

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1. Course Overview

This course will focus on the structure, function, biosynthesis, and metabolism of biomacromolecules, integrating fundamental concepts of biochemistry with advanced scientific issues, key technologies, and cutting-edge research. Topics will include nucleic acid chemistry, protein chemistry, carbohydrate chemistry, molecular evolution, and the regulation of biomacromolecular metabolism. Biological macromolecules—such as nucleic acids, proteins, carbohydrates, lipids, and other essential substances—are foundational to all life processes and physiological activities. By exploring the structure, function, metabolism, and regulation of these biomacromolecules, students will gain insights into the underlying principles and dynamics of various life phenomena, thereby advancing research and development in the biopharmaceutical industry. Biomacromolecules are central to disciplines including biological sciences, medicine, pharmacy, and agriculture. This course serves as a fundamental foundation for studies in biology, biomedicine, agricultural biotechnology, and related research fields.

2. Course Objectives

Advanced biochemistry builds on the foundational study of basic biochemistry at the undergraduate level, providing a deeper and more expansive exploration of the subject. This course equips graduate students with a thorough understanding of the structure and function of key biomacromolecules involved in physiological processes. Students will also gain insight into the core scientific issues, key technologies, and recent advancements in the metabolism and regulation of these biomacromolecules. By engaging with this course, graduate students will reinforce their fundamental biochemical knowledge from multiple perspectives. They will become proficient with advanced research techniques and methodologies. This experience will help expand their research horizons and develop independent analytical and research skills. Ultimately, these enhancements will lead to greater innovation and improved research quality.


Syllabus

  • Chapter 1 Introduction
    • Introduction
  • Chapter 2 Nucleic acid chemistry
    • 2.1 Nucleic acid structure and function
    • 2.2 Genomics
    • 2.3 Epigenetics
    • 2.4 RNA Function
  • Chapter 3 Protein chemistry
    • 3.1 Protein structure and function
    • 3.2 Structural biology
    • 3.3 Protein modification, degradation, and interaction
    • 3.4 Proteomics and Metabolic Networks
  • Chapter 4 Evolution of biological macromolecules
    • 4.1 Molecular evolution
    • 4.2 Evolution of nucleic acid and genome
    • 4.3 Protein rational design and directed evolution
    • 4.4 Population evolution and trend prediction
  • Chapter 5 Glycobiology
    • 5.1 Structure, synthesis, and function of glycoconjugates
    • 5.2 Glycosyltransferases and their applications
    • 5.3 Glycoproteomics and its applications
    • 5.4 Glyco-bioinformatics and its applications
  • Chapter 6 Metabolism and regulation of biomacromolecules
    • 6.1 Metabolic types and pathways of biomacromolecules
    • 6.2 Metabolic regulation of biomacromolecules
    • 6.3 Metabolomics and metabolic networks
  • Final exam

    Taught by

    China University of Petroleum(East China)

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