Overview

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This course explores the neurobiology and pharmacology of pain and synaptic signaling, with a focus on how drugs targeting specific receptor systems shape perception and behavior. Learners will examine fundamental mechanisms of pain transmission and gain a deeper understanding of G-protein coupled receptors using the opioid receptor as a central example. The course begins with opioid pharmacology, explaining how opioid receptor agonists produce analgesia at the molecular and circuit levels, and how repeated exposure can lead to tolerance and dependence. Current clinical guidelines and best practices in opioid prescribing are integrated to connect receptor biology with insight into medical decision-making. The course then examines endocannabinoid signaling, highlighting its unique retrograde communication system, endogenous ligands, and receptors. Students will explore the pharmacological effects of THC and synthetic cannabinoids, as well as emerging therapeutic applications and documented health risks. Finally, the course broadens its scope to consider more complex forms of synaptic communication, including silent synapses and tripartite synapses involving neuron–astrocyte interactions. Learners will also be introduced to modern genetic tools used to map neuronal connectivity, emphasizing how advances in technology continue to reshape our understanding of brain circuits. To be successful in this course, learners should have a background in biology. This course provides a strong foundation for students interested in neuroscience, pharmacology, pain research, addiction science, and related biomedical and health fields. Learners should be comfortable with basic cell biology, receptor signaling, and introductory physiology. This course is particularly well suited for learners preparing for careers in medicine, pharmacy, nursing, psychology, biomedical research, or other health-related professions. The course is also appropriate for trainees and healthcare professionals seeking a deeper mechanistic understanding of opioid and cannabinoid pharmacology, especially in the context of pain management and substance use.

Syllabus

Opioid receptors and pain

This module introduces the basic mechanisms of pain transmission and explores G-protein coupled receptors using the opioid receptor as a key example. We will learn how opioid receptor agonists produce analgesia and how their use can lead to dependence. The module also includes a video covering current guidelines and best practices in opioid prescribing.

Endocannabinoids and THC

This module examines the unique features of endocannabinoid signaling compared to other neurotransmitter systems. We will study the endogenous endocannabinoids and their receptors, along with the pharmacological actions of THC and synthetic cannabinoids. Assigned readings will highlight current developments in the therapeutic use of cannabinoids and the health risks linked to synthetic analogs.

The not-so-unusual synapse: Silent synapses and tripartite synapses

This module provides a broader view of synaptic function by examining silent synapses, where presynaptic signaling fails to elicit postsynaptic activation, and tripartite synapses, which involve interactions between neurons and astrocytes. A short video highlights recent advances in genetic tools for mapping neuronal connectivity.