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Explore the cutting-edge development and application of multi-color genetically-encoded sensors for monitoring neuromodulator dynamics in living organisms through this conference talk by Yulong Li at ICBS2025. Discover how these innovative biosensors enable real-time visualization and measurement of neuromodulator activity in vivo, providing unprecedented insights into neural signaling mechanisms. Learn about the construction principles behind multi-color sensor systems and their advantages for simultaneous detection of multiple neuromodulators. Understand the technical challenges overcome in developing these sophisticated tools and examine their applications in neuroscience research. Gain insights into how these sensors are revolutionizing our understanding of brain function by allowing researchers to spy on the dynamic behavior of neuromodulators as they operate within intact neural circuits.
