Tackling Heterogeneity in Sjögren's Disease - The Role of Stratification and Clustering

Explore the complexities of patient stratification in Sjögren's disease through this 47-minute webinar presented by Dr. Yann Nguyen from Université Paris Cité. Gain insights into the challenges of managing this autoimmune disease, which presents with diverse manifestations from dry syndrome to systemic complications and lymphoma risk. Learn about innovative approaches to patient classification, including the newly developed clustering system that identifies three distinct subgroups: BALS (B-cell active with low symptoms), HSA (high systemic activity), and LSAHS (low systemic activity with high symptoms). Understand how these clusters differ in characteristics, prognosis, and cytokine profiles, suggesting varied pathophysiological mechanisms. Benefit from Dr. Nguyen's extensive expertise as an associate professor in Internal Medicine and Clinical Immunology, whose research focuses on immune-mediated inflammatory diseases and patient stratification. Join moderators Prof. Gaetane Nocturne and Coralie Bouillot in this ERN ReCONNET presentation that addresses the critical challenge of heterogeneity in both clinical studies and disease understanding.