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Explore cutting-edge bionanoscience research in this keynote presentation delivered by Professor Dame Molly Stevens, focusing on the design and clinical translation of ultrasensitive diagnostic technologies. Discover how self-assembled peptide and protein nanoparticles, hydrogels, and bio-interfaces are revolutionizing healthcare applications including drug delivery and disease detection. Learn about high-throughput synthesis techniques for diversifying peptide libraries and surveying properties like fluorescence and supramolecular behavior. Examine nanomimicking approaches for inhibiting virus and parasite host cell entry, demonstrated for malaria, HSV-2, and SARS-CoV-2, alongside high molecular weight polymer carriers for enhanced saRNA therapeutic delivery. Understand the development of photo-responsive nanoreactors inspired by circadian rhythms and functionalised nanoparticles engineered as nanoprobes for in vivo disease diagnostics with colorimetric responses suitable for naked-eye detection. Investigate CRISPR-based preamplification-free detection of ncRNAs through CrisprZyme technology and advances in Raman spectroscopy for high-throughput, label-free characterization of single nanoparticles using SPARTAâ„¢ technology. Gain insights into translational pipelines that drive biomedical innovations from laboratory to clinical application while supporting healthcare democratization efforts. The presentation covers fundamental science balanced with practical technology development to address major healthcare challenges across diagnostics, advanced therapeutics, and regenerative medicine.
