Bioelectronic Oxygen Generating Macrodevices for the Cell-Based Delivery of Protein Therapeutics In Vivo Without Immune Suppression

Explore a groundbreaking webinar on bioelectronic macrodevices designed to revolutionize cell-based protein therapeutic delivery without requiring immune suppression. Learn about innovative wireless-powered devices that electrochemically generate oxygen to maintain therapeutic cell viability in subcutaneous implant sites, addressing the critical challenge of nutrient deprivation that has historically limited cell encapsulation technologies. Discover how these bioelectronic platforms utilize resonant inductive coupling to split water vapor into oxygen and hydrogen gas, providing essential nutrients for encapsulated therapeutic cells that secrete proteins like insulin and other biologics. Examine recent breakthrough results demonstrating 90-day diabetes reversal in rodent models and ongoing research in non-human primate studies that could translate to human applications. Understand the broader implications for treating various diseases through stimulus-responsive protein delivery, including glucose-responsive insulin therapy for diabetes and antibody therapeutics for multiple indications. Gain insights into the engineering approaches used to preserve cell function in hypoxic environments, novel immunomodulatory biomaterials that prevent fibrosis, and the unique considerations required when scaling from small animal models to large animals and primates with more complex immune systems similar to humans.