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This course offers a comprehensive and structured approach to identifying, validating, prioritizing, and selecting unmet, underserved, and unarticulated needs in healthcare, laying the foundation for meaningful, evidence-based innovation. Using a combination of real-world examples, stakeholder perspectives, and practical tools, learners will explore how to uncover high-impact opportunities that align with clinical, organizational, and policy priorities. Emphasizing both critical thinking and creative problem-solving, the course equips learners to assess the significance, feasibility, and strategic relevance of healthcare challenges, ultimately guiding them toward selecting the right opportunities for innovation. Whether learners plan to work in clinical care, health-tech startups, public health, or healthcare management, this course provides them with foundational tools to recognize and act on the right opportunities for innovation that are feasible, relevant, and aligned with stakeholder needs and systemic realities.