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Yale University

Brønsted Acidity and the Generality of Nucleophilic Substitution

Yale University via YouTube

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This course examines Brønsted acidity, pKa values, solvent effects, and nucleophilic substitution. It includes alanine titration to illustrate experimental pKa measurement and buffering, then connects these principles to organic and biochemical reactions.

Syllabus

- Chapter 1. Solvent Influence on Ionic Dissociation
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- Chapter 2. Brønsted Acidity as Nucleophilic Substitution at Hydrogen
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- Chapter 3. Understanding Relative pKa in Terms of Energy Match and Overlap
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- Chapter 4. Measuring the pKa values of Alanine
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- Chapter 5. Factors that Influence pKa over an Expanded Range
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- Chapter 6. The Generality of Nucleophilic Substitution
.

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5.0 rating, based on 1 Class Central review

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  • Anonymous
    Very interesting. I appreciated the resources shared from Harvard but am still struggling to grasp all the chem concepts here. I'll have to go more basic and revisit this one!
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