Aromatic Substitution in Synthesis: Friedel-Crafts Reactions and Benzylic Chemistry

This course examines aromatic substitution reactions used in organic synthesis, including Friedel-Crafts alkylation and acylation, diazonium intermediates, nucleophilic aromatic substitution, and benzylic reactivity. It emphasizes designing reaction sequences to access substituted benzenes.

Syllabus

- Chapter 1. Discovery of Friedel-Crafts Alkylation and Acylation
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- Chapter 2. Avoiding Friedel-Crafts Rearrangements
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- Chapter 3. Synthetic Accessibility via Aromatic Substitution. Diazonium Salts
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- Chapter 4. Nucleophilic Aromatic Substitution and NADH Reduction
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- Chapter 5. Benzylic Reactivity, Steric Hindrance, and Moses Gomberg
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