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Learn how digital microfluidics technology can revolutionize CRISPR screening workflows by miniaturizing and automating arrayed screening processes in this 33-minute webinar presented by Hugo Sinha, co-founder at DropGenie. Discover the challenges facing drug developers when conducting arrayed CRISPR screens with translatable cell models such as primary cells and iPSCs, including high costs and large cellular input requirements that often necessitate donor pooling and create heterogeneous datasets. Explore how a novel automated microfluidic system addresses these limitations by miniaturizing non-viral transfection processes while maintaining high efficiency and viability, significantly reducing the number of cells required per edit. Understand the system's capability to efficiently deliver various payloads including mRNA, DNA, proteins, and RNP across different cell types and structures, including primary immune cells and iPSCs. Examine the custom 48-plex editing cartridge and its associated workflow for automation integration, enabling thousands of edits daily without human intervention. Gain insights into how this approach enables rapid, cost-effective, high-throughput discovery at individual patient resolution, potentially reducing drug candidate attrition and advancing personalized therapies. The webinar offers PACE credits for registered Labroots members and provides practical knowledge for researchers working in drug discovery, synthetic biology, and gene editing applications.
