CRISPR Meets iPSCs - Powering the New Wave of Biomedical Discovery

Explore the transformative partnership between CRISPR gene editing technology and human induced pluripotent stem cells (iPSCs) in this 34-minute keynote presentation by Dr. Pia Johansson, Director of the Cell and Gene Technologies Core at Lund Stem Cell Centre. Discover how this powerful combination is revolutionizing biomedical research through disease modeling, functional studies, and high-throughput screening applications. Learn about the unique challenges that arise when working with iPSCs, including their susceptibility to pluripotency drift and genomic instability, particularly following gene editing procedures. Understand the critical importance of standardized methodologies, robust quality control measures, and the essential role of core facilities in maintaining research integrity and reproducibility. Gain insights into the groundbreaking opportunities offered by CRISPR-iPSC technology while examining the quality assurance measures necessary to ensure consistent, reliable, and reproducible research outcomes in this rapidly advancing field. The presentation addresses three key learning objectives: describing applications of CRISPR and iPSCs in various research contexts, explaining the technical challenges affecting iPSC research post-gene editing, and discussing how standardized approaches and core facilities support scientific rigor in CRISPR-iPSC studies.