Mutational Signatures in Cancer - Interplay of DNA Damage and Repair

Explore the intricate relationship between DNA damage and repair mechanisms in cancer through this 33-minute conference talk from the Computational Genomics Summer Institute. Delve into the computational methods used to analyze mutational signatures and understand how different DNA repair pathways contribute to the cancer mutational landscape. Learn about network-based approaches that reveal the biological processes underlying mutational patterns, including APOBEC and clock-like signatures in breast cancer. Discover how deconvolution techniques can separate DNA damage contributions from repair mechanisms in cancer genomes, and examine the computational frameworks used to identify DNA repair footprints in mutational data. Gain insights into the latest research on influence network models that uncover relationships between biological processes and mutational signatures, providing a comprehensive understanding of how computational genomics approaches are advancing cancer research and precision medicine applications.