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Explore the cutting-edge field of brain organoid technology in this 25-minute webinar presented by Dr. Gemma Gomez Giro, a leading expert in neurodevelopment and neurodegeneration research. Learn how patient-specific brain organoids serve as revolutionary three-dimensional cellular models that recapitulate key features of the embryonic human brain for studying neurodegenerative diseases in vitro. Discover the development and application of region-specific midbrain organoids as essential tools for investigating Parkinson's disease, focusing on the most affected brain regions. Understand how these complex models contain diverse cell types including dopaminergic, glutamatergic, GABAergic and serotonergic neurons, along with astrocytes, oligodendrocytes, and microglia that mirror human midbrain architecture. Examine disease-relevant phenotypes such as dopaminergic neuron loss, alpha-Synuclein aggregate formation, and neuroinflammation processes. Gain insights into phenotypic approaches for detecting disease-associated conditions and evaluating their improvement following drug treatments. Learn about the versatility of these models for screening novel small molecule drugs, anti-sense oligonucleotides, peptides, and other therapeutic approaches. Explore ongoing developments in deep phenotyping assays and computational tools designed to better detect cellular defects and measure therapeutic rescue effects. The webinar offers PACE credits for registered Labroots members and provides valuable knowledge for researchers, clinicians, and professionals working in neuroscience, drug discovery, and regenerative medicine fields.
