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YouTube

Modeling the Midbrain Floor Plate and Mature Dopaminergic Neurons with Human Pluripotent Stem Cells in 3D

Labroots via YouTube

Overview

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Watch a one-hour webinar exploring the generation of human midbrain organoids for Parkinson's Disease research, presented by Dr. Richard Josephson from Thermo Fisher Scientific. Learn how to adapt 2-D differentiation methods of floor plate to 3-D cultures while improving dopaminergic neuron yields and accelerating maturation. Discover key analysis techniques including whole-organoid imaging and multielectrode physiology for assessing neuronal function. Explore the development of disease model organoids and their applications in drug discovery research. The presentation addresses how neural organoids derived from patient-specific iPSC lines can advance understanding of human brain development, physiology, and disease progression, while discussing solutions to challenges like low throughput and poor reproducibility in 3-D cultures. Earn PACE credits valid through August 2026 by completing the webinar and following the certification process.

Syllabus

Modeling the midbrain floor plate and mature dopaminergic neurons with human pluripotent stem...

Taught by

Labroots

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