Exploring the Protein Universe via Highly Accurate Structural Predictions and Fundamentals of Protein Sequence and Structure Analysis

Attend a comprehensive scientific seminar featuring two complementary presentations on protein analysis and structural biology from Seoul National University researchers. Begin with a foundational primer by Sooyoung Cha covering the fundamentals of protein sequence and structure analysis, including sequence alignment, k-mer-based similarity search, structural alignment methods like TM-align, and the 3Di representation system that enables fast structural comparisons through Foldseek. Learn about protein clustering strategies and their necessity in large-scale datasets through illustrative examples. Continue with Martin Steinegger's main presentation exploring how computational methods MMseqs2, Foldseek, and Folddisco extract biological insights from protein sequences and structures at billion-scale, leveraging advances in structure predictors like AlphaFold2 and ESMfold to understand protein relationships and functions globally. Access additional resources including viral databases (BFVD), Foldseek tools, AlphaFold clusters, AFESM, and Folddisco platforms, plus downloadable presentation slides to accelerate your exploration of protein function and evolution through highly accurate structural predictions.