Protein Structure Search by Sequence, Fold and Pocket Pharmacophore Similarity

Learn to search protein structures in the Protein Data Bank (PDB) using three powerful similarity methods in MolSoft's ICM-Pro software. Master sequence-based searches to identify proteins with similar amino acid sequences, explore fold similarity searches to find proteins sharing three-dimensional structural patterns, and utilize pocket pharmacophore similarity searches to locate binding sites with comparable chemical properties and spatial arrangements. Discover how these complementary search approaches can accelerate drug discovery, protein function prediction, and structural biology research by efficiently identifying relevant protein structures from the vast PDB database.