Mass Photometry vs. Macro Mass Photometry - Advancing Data-Driven Decisions in Drug Development

Explore two complementary label-free analytical techniques for biomolecule characterization in this one-hour webinar presented by Maria Jacintha Victoria and Salma Jalal. Learn how Mass Photometry (MP) and Macro Mass Photometry (MMP) utilize light scattering to generate interference signals for analyzing biomolecules and therapeutic vectors directly in solution with single-particle resolution. Discover how MP measures contrast proportional to particle mass for direct mass determination, providing insights into purity, aggregation, stability, oligomeric states, stoichiometry, and affinity. Understand how MMP extends these capabilities by adding a size dimension, enabling simultaneous measurement of particle diameter and contrast as a mass proxy to better capture size distributions, heterogeneity, and stability trends. Compare both technologies side by side through application datasets across various biomolecules including proteins, mRNA, viral and non-viral vectors. Gain clear understanding of when to apply each technology and how they work together to provide comprehensive molecular quality assessment and critical attribute analysis, enabling data-driven decisions throughout the drug development pipeline from discovery through process development to QC release in GMP environments.