Columnar Nucleosome Stacking Dictates NCP and Telomeric Chromatin Condensation

Explore the critical role of nucleosome stacking in chromatin compaction through this 28-minute conference talk from the Workshop on "Chromatin Modeling" at the Erwin Schrödinger International Institute. Delve into the formation of stacked columns by isolated nucleosome core particles (NCPs) in the presence of multivalent cations, and examine how this process can be modeled using multi-scale coarse-grained simulations. Discover recent findings on the columnar structure of telomeric chromatin, revealed through Cryo-EM studies, and learn about the role of TRF2 protein in inducing this architecture. Gain insights into the modeling of ion-mediated phase separation of NCPs and understand the importance of telomere maintenance and interactions with shelterin components in chromatin condensation.