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Explore chromatin organization and dynamics through an advanced active-polymer modeling framework in this colloquium lecture by Prof. Sunil Kumar from IIT Madras. Delve into the fundamental principles governing how chromatin folds and condenses within the cell nucleus, examining the critical relationship between chromatin structure and gene regulation. Learn how condensed heterochromatin relates to transcriptional repression while open euchromatin associates with genetic activity. Discover the role of ATP-dependent chromatin remodelers in reshaping the nuclear landscape through loop formation, nucleosome sliding, eviction, and rebinding processes. Understand how this innovative modeling approach disentangles the contributions of loop-mediated compaction and nucleosome-level remodeling to condensation levels and dynamical regimes. Gain mechanistic insights into how active processes coordinate chromatin folding across multiple scales, with theoretical predictions that align with key experimental observations in the field of biological physics and soft matter research.
