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Explore the multiscale dynamics of charged protein condensates in this 30-minute conference lecture that bridges molecular-level behavior with macroscopic material properties. Discover how intrinsically disordered proteins undergo liquid-liquid phase separation to form biomolecular condensates with diverse structural and rheological characteristics. Learn about cutting-edge research that integrates physics-based simulations with experimental measurements to reveal how sequence-dependent electrostatic interactions and conformational heterogeneity drive complex behavior across multiple scales. Examine recent findings demonstrating that dilute-phase protein conformations can predict condensate mechanical properties, establishing a framework for connecting single-chain behavior to bulk material response. Investigate how local molecular motions and interactions contribute to emergent macroscopic flow and relaxation phenomena within condensates. Gain insights into the fundamental principles governing both natural biological assemblies and engineered soft materials through a comprehensive multiscale perspective that links microscopic organization to macroscopic dynamics.
