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Explore the cutting-edge research on neuroinflammation as a potential therapeutic target for chronic pain management in this 35-minute webinar presented by Dr. Andrii Domanskyi, a Senior Research Scientist at Orion Corporation with extensive expertise in neurodegenerative diseases and pain research. Discover the fundamental neuronal circuits responsible for pain perception and examine the complex interactions between neurons and non-neuronal cells in both acute and chronic pain contexts, with particular emphasis on neuroimmune interactions in osteoarthritis pain. Learn about the significant challenges in chronic pain treatment, including the limitations of current therapies and the translational gap between preclinical animal models and clinical outcomes that hampers drug development. Investigate current in vitro models utilizing primary neuronal and organotypic cultures that enable rapid assessment of new drug candidates' effects on neuronal survival, morphology, activity, and cellular interactions. Examine recent advances in developing, characterizing, and pharmacologically validating in vivo rodent models of osteoarthritis and inflammatory pain. Analyze real-world examples from pain drug development programs to understand the obstacles in translating preclinical findings into clinically successful treatments, and explore strategic approaches to improve the quality and efficiency of chronic pain drug development. Gain insights into the molecular pathways that initiate and maintain chronic pain, and understand why targeting neuroinflammation represents a promising avenue for developing novel non-opioid analgesic drugs. PACE credits are available for registered participants through March 2027.
