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Explore how cutting-edge iPSC-derived human microglia and automated assays are revolutionizing neuroinflammation research and drug discovery in this 58-minute webinar presented by Christopher Cook, PhD, and Travis Hardcastle. Discover the limitations of traditional animal-derived cell assays that lack the complexity of human microglia and learn how these constraints have historically impeded progress in developing treatments for neurodegenerative diseases including Alzheimer's, Parkinson's, and ALS. Examine how Brainxell, Editco, and Arctoris are pioneering the use of CRISPR-edited, iPSC-derived human microglia in automated, multiplexed assays to enhance disease modeling capabilities. Understand the integration of human-relevant cellular models with mid-throughput automation and comprehensive neuroinflammatory readouts, including detailed analysis of phagocytosis mechanisms, cytokine response patterns, and inflammasome modulation processes. Learn how this innovative approach combines the scalability essential for high-throughput screening with the predictive value of human cellular models, potentially transforming the landscape of neuroinflammation research and accelerating the development of effective therapeutics for neurodegenerative conditions.
