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Join a seminar from the Broad-MIT Seminars in Chemical Biology series featuring Wilfred van der Donk from the University of Illinois Urbana-Champaign as he presents "Genome Mining for New Natural Products." Discover how ribosomally synthesized and post-translationally modified peptides (RiPPs) constitute a major class of peptide natural products found across all domains of life. Learn about the ubiquity of RiPP biosynthetic genes in sequenced genomes, their vast structural diversity, and their significant role in both fighting and causing human diseases. The presentation explores innovative approaches using genome mining and synthetic biology to discover new RiPPs, which have proven to be excellent platforms for uncovering unusual chemistry involved in their biosynthesis. Recorded at the MIT Stat Center on February 10, 2025, this 59-minute talk provides valuable insights into cutting-edge research in chemical biology.
