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Explore the fascinating world of post-transcriptional RNA modifications in this seminar from the Broad-MIT Seminars in Chemical Biology series. Delve into the groundbreaking research of Prof. Chuan He from the University of Chicago as he discusses the discovery of RNA demethylases FTO and ALKBH5, which catalyze oxidative demethylation of N6-methyladenosine (m6A) in mammalian messenger RNA. Learn about the potential impact of reversible RNA modifications on biological regulation, similar to DNA and histone modifications. Gain insights into proteins that recognize m6A-modified mRNA and their effects on RNA translation and lifetime. Discover the latest findings on transcriptional regulation through m6A methylation and demethylation, and their implications for mammalian early development and plant growth. Explore new chemical methods developed for sequencing various RNA modifications at base resolution with modification stoichiometry.
