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The Open University

Cell signalling

The Open University via OpenLearn

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Overview

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This free course, Cell signalling, explains the general principles of signal transduction and specifically, how even the simplest organisms can detect and respond to events in their ever-changing environment.

Syllabus

  • Introduction
  • Learning outcomes
  • 1 General principles of signal transduction
  • 1 General principles of signal transduction
  • 1.1 Introduction
  • 1.2 Extracellular signals can act locally or at a distance
  • 1.2.1 Cell–cell contact-dependent signalling
  • 1.2.2 Cell–cell signalling via secreted molecules
  • 1.3 Most receptors are on the cell surface
  • 1.4 Cellular responses are diverse
  • 1.5 Signal transduction mechanisms
  • 1.6 Signalling proteins can act as molecular switches
  • 1.7 Localization of signalling proteins
  • 1.8 Protein–protein interactions in signal transduction
  • 1.9 Summary
  • 2 Receptors and their ligands
  • 2 Receptors and their ligands
  • 2.1 Introduction
  • 2.2 Receptor specificity
  • 2.3 Receptor activation
  • 2.3.1 Ion-channel receptors
  • 2.3.2 Seven-helix transmembrane (7TM) receptors
  • 2.3.3 Receptors with intrinsic enzymatic activity
  • 2.3.4 Recruiter receptors
  • 2.4 Receptor inactivation
  • 2.5 Intracellular receptors
  • 2.6 Summary
  • 3 Intracellular signalling components
  • 3 Intracellular signalling components
  • 3.1 Introduction
  • 3.2 Trimeric G proteins
  • 3.3 Lipid-modifying enzymes
  • 3.3.1 Phosphatidylinositol 3-kinase (PI 3-kinase)
  • 3.3.2 Phospholipase C (PLC)
  • 3.4 Second messengers
  • 3.4.1 Calcium ions
  • 3.4.2 Cyclic AMP
  • 3.4.3 Cyclic GMP
  • 3.5 Monomeric G proteins
  • 3.6 Protein kinases
  • 3.6.1 The MAP kinase pathway
  • 3.6.2 The JAK–STAT pathway
  • 3.7 Protein phosphatases
  • 3.8 Activation of transcription factors
  • 3.9 Summary
  • 4 Glucose metabolism: an example of integration of signalling pathways
  • 4 Glucose metabolism: an example of integration of signalling pathways
  • 4.1 Glucose metabolism
  • 4.2 Summary
  • Conclusion
  • References
  • Acknowledgements

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Reviews

4.0 rating, based on 1 Class Central review

4.1 rating at OpenLearn based on 12 ratings

Start your review of Cell signalling

  • Profile image for K.N.L. Prasanna
    K.N.L. Prasanna
    In this course, I had learnt about principles of Cell signalling,responses to different signals through different signal transduction pathways,different receptors and ligands participating in cell signalling.Through glucose metabolism the pathways ,the proteins and their interactions in cell signaling are also important to learn.Totally ,at every module i really enthusiastically learned from point to point and learnt many things from this course.
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