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Hormones and Signal Transduction

via Coursera

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Details

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Provider

Coursera
Pricing

Paid Course
Languages

English
Certificate

Certificate Available
Effort

4 weeks, 2 hours a week
Sessions

Self-Paced
Level

Beginner
Subtitles

English

Found in

Overview

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Hormones let distant cells communicate, and signal transduction is how a target cell converts that message into an internal response. This course introduces the major classes of hormones and how they interact with the cell membrane, then works through G-protein coupled receptor (GPCR) signaling in detail: G-protein structure, the second messenger cAMP, protein kinase A, and how beta-adrenergic receptor signaling is switched off. You'll then cover receptor tyrosine kinase (RTK) signaling, including the insulin receptor and GLUT-4, and the epidermal growth factor receptor (EGFR) pathway, before turning to nuclear hormone receptors and steroid hormone signaling, and non-hormone signaling in nerve transmission. The course closes with signal transduction in disease, covering oncogenes, RAS and SRC mutations, HER2 and the Philadelphia chromosome, and how tyrosine kinase inhibitors are used to treat the cancers these pathways cause.

Syllabus

Introduction to Signal Transduction and GPCR Signaling
- This module introduces how hormones signal to cells and traces the G-protein-coupled receptor pathway in detail, from receptor and G-protein activation through cAMP and protein kinase A signaling to how the pathway is switched off.
Receptor Tyrosine Kinase Signaling
- This module covers receptor tyrosine kinase signaling through the insulin receptor and EGFR pathways, including the role of the RAS protein and how these pathways are inactivated.
Nuclear Hormone Receptors and Non-Hormone Signaling
- This module covers how nuclear hormone receptors mediate steroid hormone signaling and contrasts this with non-hormone signaling mechanisms such as nerve transmission.
Signal Transduction in Disease
- This module covers how mutations in signaling proteins, including RAS, SRC, HER2, and the Philadelphia chromosome's BCR-ABL fusion, drive cancer development and how targeted therapies such as tyrosine kinase inhibitors address them.