Cell Signaling

ABOUT THE COURSE:The course will emphasize on the fact that all living beings respond to environmental as well as cues initiated from other living organisms. Our growth (post-partum and embryonic more so) is well connected to responses we mount to the signaling. In this Course I will primarily focus on how living beings engage in signaling to stay healthy and grow normally. The focus will largely be on the receptors prevalent in the animal kingdom primarily in Mammals, but I will also introduce aspects of microbial and plant signaling events.PREREQUISITES: A course in Cell Biology and Molecular BiologyINDUSTRY SUPPORT: Anti-cancer and physiology related drug developing industry, Biosimilars

Syllabus

Week 1: Cell signaling, components and types of signaling
Week 2:Types of ligand, regulation of ligand, receptor binding proteins, G-proteins and signaling
Week 3:Kinases, Types of receptors, Mechanoreceptors, Structure and Function, Receptor activation, modes of intracellular signaling
Week 4:Signaling in Microbial world, Two-component signaling,
Week 5:Receptors Serine-threonine kinase, diversity in receptor activation
Week 6:Discovery of Tyrosine kinases, Receptor tyrosine kinase (RTK) signaling ,diversity in RTKs
Week 7:Growth factor signaling, cancer and diseases due to RTK malfunction,
Week 8:G-protein coupled receptor (GPCRs), G-proteins type, regulation of GPCR signaling