Versatility of Mass Photometry for the Structural Characterization of Biomolecular Assemblies

Explore the versatility of mass photometry as a powerful analytical technique for characterizing biomolecular assemblies in this 46-minute webinar. Discover recent applications focusing on higher-order protein assemblies found in blood, with particular emphasis on the technique's ability to analyze co-occurring assemblies simultaneously. Learn how mass photometry data enabled researchers to propose improved structural models for the C4b-binding protein (C4BP) macromolecular assembly and gain deeper insights into exploiting multivalency in antibody therapeutics to optimize antibacterial biotherapeutics. Understand how mass photometry complements other structural biology techniques including glycoproteomics, cross-linking mass spectrometry, native mass spectrometry, computational modeling, and single molecule mass spectrometry. Gain practical knowledge about mass photometry's ease of use and versatility, its capability to assess protein assembly purity, and its application in quantifying co-occurring protein assemblies. Discover surprising findings about blood composition and learn why IgM antibodies may sometimes outperform IgG as biotherapeutic agents in certain applications.