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This webinar presented by Professor Melanie Bailey, PhD, explores the SEISMIC facility, a new BBSRC national multi-user facility for spatially resolved single and sub-cellular "omics" analysis. Discover how single-cell analysis is revolutionizing our understanding of cellular mechanisms behind pathogenesis and treatment of diseases like cancer. Learn about capillary sampling techniques used to sample live cells or sub-cellular compartments under microscope observation, and how these methods can be coupled with chromatographic separation to mitigate matrix effects and aid peak assignment. The presentation covers how live single-cell lipidomics can be achieved using capillary-sampled cells and microfluidics, demonstrates the performance capabilities of state-of-the-art mass spectrometry systems, and shows practical applications revealing how single cell lipid profiles of cancer cells respond to drug and radiation treatment. The 45-minute session also reports on progress towards sub-cellular sampling and mass spectrometry metallomics and proteomics analysis, providing valuable insights for researchers interested in advanced bioanalytical techniques.
