Explore cutting-edge super-resolution imaging techniques for studying chromatin structure and dynamics in health and disease through this invited lecture by Dr. Melike Lakadamyali at the 2024 Symposium on Physical Genomics. Gain insights into the pioneering developments in super-resolution microscopy that have enabled novel understanding of vesicle transport along cytoskeletal tracks and the spatial organization of nucleosomes along chromatin fibers. Learn about the quantitative biophysical approach taken by Dr. Lakadamyali's group in studying these biological processes, moving beyond qualitative descriptions to precise quantitative models. Discover the implications of this research for understanding chromatin structure and dynamics in both healthy and diseased states.