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Explore cutting-edge techniques for optimizing genome assembly using HiFi reads in this 35-minute conference talk from the Computational Genomics Summer Institute. Delve into the latest advancements in de novo assembly methods, focusing on complex eukaryotic genomes and metagenomes. Learn about innovative tools like RAmbler for handling repetitive regions and Hifiasm for haplotype-resolved assemblies. Discover strategies for integrating optical mapping techniques to improve scaffolding and reconciliation of genome assemblies. Gain insights from comprehensive assessments of various HiFi assemblers and their performance on challenging genomic structures, including the complete human chromosome 8.
