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Explore somatic mutation analysis in cancer samples using TumorLens, a novel computational tool designed for long-read sequencing data analysis. Learn how Oxford Nanopore sequencing technology overcomes limitations of short-read sequencing by analyzing repetitive and complex genomic regions while simultaneously capturing epigenetic modifications. Discover how genomic instability drives cancer through various somatic mutations, from single nucleotide substitutions to large-scale chromosomal rearrangements that disrupt cellular pathways and contribute to tumor progression. Understand the methodology behind detecting somatic mutations and methylation changes genome-wide, with particular focus on identifying HLA loss of heterozygosity (LoH) at both genetic and epigenetic levels. Gain insights into how long-read sequencing provides more complete and accurate assessment of complex genetic variations in cancer research. The presentation is delivered by Dr. Luis Felipe Paulin Paz, who brings expertise in statistical models for RNA-sequencing, structural variant detection, and cancer genomics tool development including Sniffles2 and Spectre. Earn PACE credits by completing the webinar requirements through the Labroots platform.
