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Explore DNA methylome analysis techniques in this 31-minute conference talk that covers the evolution from short-read to long-read sequencing technologies. Learn about comprehensive approaches to analyzing genome-wide DNA methylation profiles using established tools like methylKit, an R package for methylation analysis. Discover dynamic clonal epiallele evolution through methclone methodology and examine the latest developments in DNA methylation-calling tools specifically designed for Oxford Nanopore sequencing platforms. Gain insights into comparative evaluations of methylation analysis methods across human epigenome-wide studies, understanding both the capabilities and limitations of current sequencing technologies for epigenetic research.
