Evolution of Phenotypic Plasticity Leads to Tumor Heterogeneity with Implications for Therapy

Explore how evolutionary processes drive phenotypic plasticity in cancer cells, leading to tumor heterogeneity with significant therapeutic implications in this 19-minute conference talk. Delve into the mathematical modeling approaches used to understand how cancer cells adapt and diversify their characteristics in response to treatment pressures. Learn about the mechanisms by which tumor cells develop plasticity, allowing them to switch between different phenotypic states and create diverse cell populations within a single tumor. Examine the clinical consequences of this heterogeneity for cancer treatment strategies and discover how mathematical oncology provides insights into predicting and potentially overcoming treatment resistance. Gain understanding of the evolutionary dynamics that govern tumor progression and the role of cellular plasticity in shaping cancer outcomes.