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Explore non-genetic mechanisms by which tumors evade treatment and develop resistance in this 27-minute didactic lecture from Mathematical Oncology. Delve into the mathematical modeling approaches used to understand how cancer cells can escape therapeutic interventions through epigenetic changes, cellular plasticity, and other non-mutational pathways. Learn about the theoretical frameworks and computational methods that help explain tumor heterogeneity and treatment failure beyond traditional genetic mutation models. Gain insights into how mathematical oncology research is advancing our understanding of cancer evolution and informing new therapeutic strategies that account for these alternative escape mechanisms.
