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Explore the cutting-edge intersection of wearable technology and space exploration in this keynote presentation from RIOT Summit 2025. Delve into the critical need for continuous health monitoring systems for astronauts during future Moon and Mars missions, where environmental conditions pose unique physiological challenges that differ significantly from those encountered on the International Space Station. Learn about the research gaps in space-capable wearables and discover how miniaturized, efficient sensor systems are being developed to address the harsh conditions of deep space environments. Examine the 'SpacePatch' project as a practical example of space-ready wearable technology, featuring RIOT as its operating system, and gain insights from recent spaceflight test results. Understand the technical challenges involved in creating reliable sensor technologies for space environments, including considerations for radiation effects, fault tolerance, and energy efficiency. The presentation covers hardware-software co-design principles for embedded systems in space applications and discusses the technology transfer potential from space electronics to terrestrial applications. Gain perspective on future research directions in smart sensor systems for space exploration and the role of embedded fault diagnosis in ensuring mission-critical wearable devices function reliably in extreme environments.