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Intro
Learning objectives
1. What is EBM
What steps are involved in EBM?
2. Introduction to critical appraisal
Detailed Critical appraisal of a Journal Article
Core questions for initial evaluation of a scientific article
Critical appraisal - modes of research
Hierarchy of evidence - Traditional levels
Hierarchy of evidence - Grading
Grading of clinical evidence
Hierarchy of evidence and corresponding databases
Proposed new pyramid
What about qualitative research?
EBM vs EBP
Key steps in evidence-based practice
Clinical reasoning and critical appraisal
Practice of high-value evidence based laboratory medicine
Introducing the principles of EBLM into routine practice
How to apply EBLM when evaluating new laboratory tests
Biomarker validation approach
R&D flowchart in the lab
R&D process in the lab for new biomarkers
Qualification of Biomarkers
Chemical Pathologist roles involved in Research and Development
The Royal College of Pathologists
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